Search results for "Esclerosis amiotrófica lateral"

showing 3 items of 3 documents

Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study

2019

Background: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, characterized by progressive loss of spinal and cortical motor neurons, leading to muscular atrophy, respiratory failure, and ultimately death. There is no known cure, and the clinical benefit of the two drugs approved to treat ALS remains unclear. Novel disease-modifying therapeutics that are able to modulate the disease course are desperately needed. Our objective was to evaluate the efficacy and tolerability of Elysium Health's candidate drug EH301 in people with ALS (PALS). Methods: This was a single-center, prospective, double-blind, randomized, placebo-controlled pilot study. Thirty-two PALS we…

MaleVital CapacityPilot ProjectsGastroenterologylaw.inventionPlacebos0302 clinical medicineRandomized controlled triallawStilbenesMedicineAmyotrophic lateral sclerosisMedicamento1-(beta-D-Ribofuranosyl)nicotinamide chlorideMiddle AgedDrug CombinationsTreatment OutcomeNeurologyTolerabilityDisease ProgressionFemale35-Dimethoxy-4′-hydroxy-trans-stilbeneNiacinamidemedicine.medical_specialty3Investigación médicaPlaceboDouble blind03 medical and health sciencesAtrophyDouble-Blind MethodInternal medicinerandomized control studyHumansMuscle StrengthhumanAgedElectromyographybusiness.industryAmyotrophic Lateral Sclerosismedicine.diseaseAmyotrophic lateral sclerosis5-Dimethoxy-4 '-hydroxy-trans-stilbeneMétodo doble ciego1-(beta-D-Ribofuranosyl) nicotinamide chlorideRibonucleosidesNeurology (clinical)business030217 neurology & neurosurgeryEsclerosis amiotrófica lateral
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Muscle Function Differences between Patients with Bulbar and Spinal Onset Amyotrophic Lateral Sclerosis. Does It Depend on Peripheral Glucose?

2021

Background: One of the pathogenic mechanisms of ALS disease is perturbed energy metabolism particularly glucose metabolism. Given the substantial difference in the severity and the prognosis of the disease, depending on whether it has a bulbar or spinal onset, the aim of the study was to determine metabolic differences between both types of ALS, as well as the possible relationship with muscle function. Materials and Methods: A descriptive, analytical, quantitative, and transversal study was carried out in hospitals and Primary Care centers in the region of Valencia, Spain. Fasting glucose and alkaline phosphatase (AP) levels in venous blood, muscle percentage, fat percentage, muscle streng…

amyotrophic lateral sclerosis:Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose [Medical Subject Headings]lcsh:Medicine:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behavior::Fasting [Medical Subject Headings]DiseaseGastroenterology:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]0302 clinical medicineAmyotrophic lateral sclerosisglucosespinal onset ALS:Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Phosphoric Monoester Hydrolases::Alkaline Phosphatase [Medical Subject Headings]:Health Care::Health Care Facilities Manpower and Services::Health Facilities::Hospitals [Medical Subject Headings]0303 health sciences:Anatomy::Musculoskeletal System::Muscles [Medical Subject Headings]General MedicineVenous bloodFuerza muscular:Health Care::Health Services Administration::Patient Care Management::Comprehensive Health Care::Primary Health Care [Medical Subject Headings]PeripheralAlkaline phosphataseFosfatasa alcalinaalkaline phosphatasemedicine.medical_specialtyBarthel indexbulbar onset ALS:Diseases::Nervous System Diseases::Neurodegenerative Diseases::Motor Neuron Disease::Amyotrophic Lateral Sclerosis [Medical Subject Headings]Carbohydrate metabolismResistencia a la insulinaArticle03 medical and health sciences:Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance [Medical Subject Headings]Insulin resistance:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Muscle Strength [Medical Subject Headings]Internal medicinemedicine030304 developmental biology:Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings]Muscle strengthbusiness.industrylcsh:RInsulin resistance:Phenomena and Processes::Metabolic Phenomena::Metabolism::Energy Metabolism [Medical Subject Headings]medicine.diseaseAtrofia muscular espinalGlucosa:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings]businessEsclerosis amiotrófica lateral030217 neurology & neurosurgery
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Ingesta nutricional en pacientes afectados de esclerosis lateral amiotrófica una consulta ambulatoria de nutrición artificial en Portugal

2021

Introducción: La Esclerosis Lateral Amiotrófica (ELA) es una patología neurodegenerativa crónica y progresiva, que produce la muerte de las motoneuronas. Deriva en pérdida de peso, de masa muscular e incremento de deficiencias nutricionales. Existe relación entre la ingesta nutricional y la patogénesis de la ELA. El objetivo de este análisis fue describir las características sociodemográficas, antropométricas y clínicas junto con la ingesta nutricional en una muestra de pacientes portugueses afectados de ELA. Material y Métodos: Se realizó una anamnesis clínica breve. El peso corporal fue evaluado siguiendo el protocolo de la International Society for the Advancement of Kinanthropometry (IS…

medicine.medical_specialtyEsclerosis Amiotrófica LateralRC620-627ConstipationAntioxidantesWeight lossInternal medicinemedicineVitamin D and neurologyTX341-641Amyotrophic lateral sclerosisEstado NutricionalNutritional diseases. Deficiency diseasesAnamnesisNutrition and DieteticsPortugalNutrition. Foods and food supplybusiness.industryIngestión de AlimentosAnthropometrymedicine.diseaseMalnutritionDietary Reference Intakemedicine.symptombusinessFood ScienceRevista Española de Nutrición Humana y Dietética
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